S.K. Chung et al. suggested that XAF1 expression suppressed tumor cell growth, led to caspase-3 activation and enhanced the apoptotic sensitivity of tumor cells to various apoptotic stimuli in colorectal tumors, while siRNA-mediated knockdown of XAF1 greatly enhanced cellular survival under apoptotic stresses (30). Here, CASP3 is linked to colorectal neoplasm.