S.K. Chung et al. suggested that XAF1 expression suppressed tumor cell growth, led to caspase-3 activation and enhanced the apoptotic sensitivity of tumor cells to various apoptotic stimuli in colorectal tumors, while siRNA-mediated knockdown of XAF1 greatly enhanced cellular survival under apoptotic stresses (30). The gene discussed is XAF1; the disease is colorectal neoplasm.