A comprehensive molecular analysis of 333 primary PCa samples from The Cancer Genome Atlas (TCGA) defined seven subtypes based on erythroblast transformation specific transcription factors (ETS) fusions or mutations in SPOP, forkhead box A1 (FOXA1), and isocitrate dehydrogenase 1 (IDH1), but demonstrated a substantial epigenetic heterogeneity within the subgroups (70). Here, SPOP is linked to posterior cortical atrophy.