HOPX and acute myeloid leukemia: However, in AML patients who have undergone allogeneic hematopoietic stem cell transplantation, BAALC expression had no prognostic effect.26BAALC was found to block myeloid differentiation and promote leukemogenesis.12 Furthermore, in pediatric AML patients, BAALC and ERG expressions were shown to associate with low induction remission.27,28 BAALC overexpression was found in a group of genes which were identified as a high risk group for survival with MN1, SPARC, HOPX genes.22