HER2 activates multiple signaling axes, especially in MAPK signaling system and STAT3; leading to rapid tumor proliferation and cancer metastasis.15 HER2 also promotes epithelial-mesenchymal transition (EMT) by upregulating TGFβ/SNAIL-ZEB1, activates a Wnt-dependent EMT-like dissemination program, and downregulates E-cadherin expression.16,17 Interestingly, the increase of HER2 expression could be observed in metastatic cancer cells even though the primary tumor is HER2 negative.15,18. This evidence concerns the gene ZEB1 and neoplasm.