Since we did not find significant differences of the PGV-1 treatment on HER expression profiles, we then evaluated the efficacy focusing on PGV-1 against tumor xenograft using 4T1 cells, a highly tumorigenic HER2- and metastatic cell line, which are suitable for our purpose in developing an anti-metastatic agent.27 We used curcumin as the comparison. Here, ERBB2 is linked to neoplasm.