Moreover, PMPs which contain a certain epidermal growth factor receptor (EGFRvlll) typically expressed by gliomas cells, can transfer this oncogenic receptor to cancer cells lacking it, promoting their oncogenic activity.174 Nevertheless, Mege et al reported a decrease in PMP concentration in colorectal cancer patients compared to healthy individuals, which does not agree with Hron et al study122 showing higher TF positive-PMP levels in advanced colorectal cancer patients in comparison with healthy subjects.174. The gene discussed is TF; the disease is cancer.