The interaction between CD40L on platelets and PMPs’ surface with CD40 on pre-B ALL cells has also resulted in increased Fas expression in tumor cells which in turn induces apoptosis.143,144 Yet another study demonstrated that CD95L and CD95 possess several cancer related tumor-promoting and non-apoptotic functions, protecting and promoting cancer stem cells.145. Here, FAS is linked to acute lymphoblastic leukemia.