CD146 is a membrane receptor that was originally found to be highly expressed in metastatic lesions and advanced primary tumors;[17, 18] however, experimental evidence also suggests that CD146 is a multifunctional cell adhesion molecule with crucial roles in angiogenesis and inflammatory diseases.[19, 20, 21, 22, 23] Recently, we demonstrated that CD146 interacts with CD36, a receptor responsible for ox‐LDL uptake, to promote foam cell formation and retention during atherosclerosis;[24] thus, CD146 may affect obesity development and obesity‐related chronic inflammation. The gene discussed is MCAM; the disease is obesity due to melanocortin 4 receptor deficiency.