Obesity is associated with many health problems, including insulin resistance and chronic inflammation.[26] Insulin resistance leads to a compensatory increase in plasma insulin levels and decreased glucose uptake.[27] When fed an HFD, the WT mice exhibited lower insulin sensitivity and glucose tolerance, whereas CD146 knockout significantly improved insulin sensitivity and glucose tolerance (Figure 2G). This evidence concerns the gene MCAM and obesity due to melanocortin 4 receptor deficiency.