After 6 weeks, body and WAT weight were significantly reduced in the AA98‐treated group compared to the mIgG control group (Figure 8D,E) whereas AA1 anti‐CD146 antibodies failed to protect the mice from obesity, consistent with the finding that AA98 but not AA1 blocks the interactions between CD146 and its ligands (Figure 8D,E). This evidence concerns the gene MCAM and obesity due to melanocortin 4 receptor deficiency.