MCAM and obesity due to melanocortin 4 receptor deficiency: Obesity mainly occurs due to an imbalance in energy homeostasis, high energy intake, and low energy expenditure.[29] Although energy intake is normally reflected by food intake, we found that CD146 KO mice consumed more food than WT mice on either the ND or HFD (Figure S5A, Supporting Information), seeming to contradict the observation that CD146 KO mice were leaner than WT mice.