Since previous studies have shown that galectin‐1 and galectin‐3 play important roles in obesity and interact with CD146 in the endothelium,[43, 44, 45, 46, 47, 48, 49] we examined whether these proteins regulated UCP1 expression in BAT. The gene discussed is UCP1; the disease is obesity due to melanocortin 4 receptor deficiency.