Therefore, ANGPTL2 can promote obesity and adipose inflammation in multiple ways: 1) ANGPTL2 binds to integrin in the endothelium to promote macrophage infiltration via NF‐κB signaling, 2) ANGPTL2 binds to CD146 to increase inflammatory adipokine (TNF‐α, IL‐6, and IL‐1β) expression by activating CREB in adipocytes. This evidence concerns the gene ANGPTL2 and obesity due to melanocortin 4 receptor deficiency.