MAP2K1 and endometrial cancer: Moreover, multiple studies have shown that overexpression of SOX2 is contributing to cancer pathogenesis.[57] In endometrial cancer, SOX2 expression is correlated with unfavorable histological grade and poor prognosis in patients, suggesting that SOX2 may be a critical factor for the proliferation of EC cells.[35] These data nicely demonstrated that the dysregulation of IGF2BP1 by PADI2/MEK1/ERK signaling axis may result in abnormal accumulation of oncogenic SOX2 expression, and therefore supports the malignant state of EC (Figure 7K).