AKAP1 and obesity due to melanocortin 4 receptor deficiency: To investigate the roles of AKAP1 in HFD‐induced obesity, we successfully generated AKAP1 knockout (AKAP1−/−) mice using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) /CRISPR‐associated protein 9 (Cas9) system (Figure S1, Supporting Information).