To investigate the roles of AKAP1 in HFD‐induced obesity, we successfully generated AKAP1 knockout (AKAP1−/−) mice using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) /CRISPR‐associated protein 9 (Cas9) system (Figure S1, Supporting Information). The gene discussed is AKAP1; the disease is Obesity.