INS and obesity due to melanocortin 4 receptor deficiency: A previous study has showed that CPT1 (a rate‐limiting enzyme in FAO) activity and FAO is decreased in BAT of diabetic rats.[24] Moreover, enhancing FAO by CPT1 overexpression significantly decreases TG content and improves insulin sensitivity under obese conditions.[25, 26, 27] These findings suggest that enhancing FAO may be an appealing strategy to increase energy expenditure and fight against obesity‐induced metabolic disorders.