UCP1 and obesity due to melanocortin 4 receptor deficiency: Thermogenic adipocytes burn fat to drive heat production by uncoupling‐protein‐1 (UCP1)‐dependent uncoupling of mitochondrial oxidative phosphorylation (OXPHOS) or UCP1‐independent modes, which mainly involve futile creatine and calcium cycling and/or triglyceride (TG)/free fatty acid (FFA) cycling.[2, 3, 4] The thermogenic ability of BAT makes it an attractive strategy to reverse obesity.