DDIT3 and impulse control disorder: While most ICD responses are categorized as “Type I” responses, “Type II” responses have been linked to agents that generate a primary ER stress response and ROS production, e.g., hypericin‐induced photodynamic therapy[47] and Pt‐N‐heterocyclic carbene.[48] We now demonstrate that IRIN, both as a free or an encapsulated drug format, induces robust ROS production and ER stress, and CHOP expression (Figures 1, 2, 3).