A similar finding that EGCG induced a drastic decrease in the phosphorylation of STAT3 and led to downregulation of the target gene products of STAT3, such as Bcl-2, VEGF, MCL-1, and cyclin D1, was also found in neck-squamous-cell-carcinoma HNSCC cells [29]. This evidence concerns the gene STAT3 and head and neck squamous cell carcinoma.