In HCC, fatty-acid biosynthesis genes such as fatty-acid synthase (FASN) and ATP citrate lyase (ACLY), cholesterol biosynthesis gene 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and adipogenesis transcriptional regulators such as sterol regulatory element-binding protein 1 (SREBP1) are upregulated [94]. This evidence concerns the gene HMGCR and hepatocellular carcinoma.