TNF and rheumatoid arthritis: During macrophage process, TNF‐α promotes the rheumatoid arthritis while supplementation of thymoquinone (1‐5 μM) significantly suppressed the IL‐8 production, TNF‐α‐induced IL‐6 and VCAM‐1, ICAM‐1, and cadherin‐11 (Cad‐11) expression.