Hatiboglu and their colleagues explored the in vitro cytotoxic effect of thymoquinone dose‐dependently on B16‐F10 melanoma cell of mice, and intracerebral melanoma in vivo enhanced the cytotoxicity through inducing the apoptosis and DNA damage, enhancing the intracellular reactive oxygen species, suppressing the p‐STAT3, and regulating the proapoptotic and antiapoptotic proteins (Hatiboglu et al., 2018). Here, STAT3 is linked to melanoma.