POLA1 and hepatocellular carcinoma: Some of the genes forming the Amerind signature (e.g., BRCA1, FANCD2, MKI67, POLA1, POLD3, SOX9, YWHAZ, and ZNF207) were displaying a stronger correlation of expression (either positive or negative) with PRC2 components in Peruvian HCC than in tumors from elsewhere, suggesting that PRC2 complex might be a key-driver of Peruvian liver tumorigenesis (Figure 3B).