More importantly, the Amerind signature for HCC is remarkably enriched with genes involved in the Hippo/YAP1, MYC, and Wnt/β-catenin pathways, as well as in Polycomb epigenetic repressors and DNA repair effectors (e.g., BRCA1, FANCD2, and TP53). Here, TP53 is linked to hepatocellular carcinoma.