Using flow cytometry we found that approximately 70% of CLL cells co-express intracellular GLI1 and phosphoserine STAT3 (Figure 1C), and using confocal microscopy we demonstrated the presence of both GLI1 and phosphoserine STAT3 in the cytoplasm and nucleus of CLL cells (Figure 1D). The gene discussed is STAT3; the disease is B-cell chronic lymphocytic leukemia.