MMP9 and cardiomyopathy: In conclusion, the present study on the one hand highlights the role of MMPs, especially gelatinase-B, in HG-induced cardiomyopathy in rat heart-derived H9C2 cardiomyoblast cells, and on the other hand, it elaborates the role of S. cumini MSE in suppressing HG-stimulated gelatinase-B expression and activity in cardiomyocytes.