TP53 and skin neoplasm: Moreover, in a mouse skin cancer model, eugenol displayed chemopreventive properties, reducing the incidence and size of skin tumors and improving animal survival rates through apoptosis stimulation, cellular proliferation inhibition, and restriction of skin carcinogenesis at the dysplastic stage via c-Myc and H-ras oncogene downregulation and p53 tumor suppressor gene expression upregulation [96].