PRDX1 cooperates with thioredoxin in inhibiting ROS-induced tumor cell apoptosis and promoting tumor cell survival by involving different types of kinases and enzymes, such as apoptosis signal-regulating kinase 1, p66Shc, and glutathione S-transferase pi (GSTpi)/c-Jun NH2-terminal kinase (JNK) [19, 36]. This evidence concerns the gene MAP3K5 and neoplasm.