IL6 and coronary artery disorder: In this regard, it has been hypothesized that conditions such as periodontitis and Coronary heart diseases may determine the increased release at the serum and salivary levels of IL-1, IL-6, prostaglandins, metalloproteases, NO, and hs-CRP, which, in turn, negatively influences the tone of the endothelial wall and, finally, causes a high risk of endothelial dysfunction and CHD development [2].