The main findings of this study were as follows: (i) serum asprosin levels were markedly higher in MetS patients than in healthy controls, and they showed an increasing trend with increasing numbers of metabolic components; (ii) serum asprosin levels were positively correlated with BMI, waist circumference, FPG, 2h-PG, FIns, HOMA-IR, TG, MCP-1, and IL-6 and negatively correlated with HDL-C; (iii) serum asprosin was independently and positively correlated with the occurrence of MetS and IR, even after controlling for the covariates. The gene discussed is IL6; the disease is metabolic syndrome.