They were found in tracks unrelated or vaguely related to the phenotype of the disorder caused by the mutation, e.g., HBA2 enhancer overlapped only the stomach accessible chromatin track from ENCODE, and the ACTN4 promoter causing focal segmental glomerulosclerosis was found in ENCODE TF-binding site tracks of erythroblasts, liver, gastroesophageal sphincter, and accessible chromatin in uterus. Here, TF is linked to focal segmental glomerulosclerosis.