Proteobacteria showed abundant shifts in tumor samples. It appears that H. influenza strain is associated with genes in the G2M control point, E2F transcription, and mitotic spindle assembly pathways, and L. fleischmannii strain is associated with genes including epithelial to mesenchymal transition. The relationship between S. pyogenes abundance and GUSBP4, GUSBP9, and GPA2 expression levels shows the role of this species in the exposure of the local breast environment to higher estrogen levels. The gene discussed is GUSBP4; the disease is neoplasm.