CD8A and nonpapillary renal cell carcinoma: Indeed, a multi-omics analysis by Clark et al. found that the TIME of ccRCC can be classified into different subtypes, namely the immunoinflammatory subtype with infiltration of CD8+ T cells that have high expression of immune checkpoint molecules, the immunosuppressive subtype with predominant infiltration of suppressor cells such as TAMs, and the immune-silenced subtype with active angiogenesis and the lack of immune cell infiltration (50).