ccRCC has relatively unique genomic features compared to other RCC types, namely chromosomal 3p deletion (>90%), chromosomal 5q gain (>67%), and somatic mutations closely related to 3p deletion events, including mutations in VHL, PBRM1, SETD2, and BAP1 (127). The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.