CIITA and neoplasm: Allogeneic anti-CD19 CAR T cells triple-knockout for HLA class I (β2-microglobulin KO), class II (CIITA KO) and TCR (α-chain KO) showed better persistence than double-knockout (β2-microglobulin and TCR) cells in a mouse tumor model, with anti-tumor activity, but without GVHD (103).