Additionally, increased TMB has been linked to PD1/PD-L1 therapeutic response, and we found that HNRNPA2B1 mRNA levels were correlated to multiple types of cancers, including ACC, stomach adenocarcinoma (STAD), thymoma (THYM) etc. Microsatellite instability (MSI) is a pattern of hypermutation caused by defects in the mismatch repair system and has been known to be both predictive and prognostic to better profile responses to anti-PD-1 immunotherapy (39). This evidence concerns the gene CD274 and adrenal cortex carcinoma.