SNP was responsible for most variants, and single nucleotide variants (SNVs) mostly occurred as C > T and C > A. The top ten mutated genes in ACC samples were TTN, MUC16, PKHD1, TP53, CTNNB1, CNTNAP5, SVEP1, LRP1, HMCN1, and ASXL3 (Figure 7A). The gene discussed is PKHD1; the disease is adrenal cortex carcinoma.