Next to insufficient H60 presentation, the GVL effect in this model failed due to the development of leukemia-specific T cell exhaustion, characterized by expression of the inhibitory receptors PD-1, TIGIT, LAG3, and TIM3 and the transcription factor TOX, which has recently been shown to drive T cell exhaustion (57–61). This evidence concerns the gene HAVCR2 and leukemia.