Subsequently, comprehensive immuno-phenotyping of AML blasts before and after allo-HCT revealed an upregulation of PD-L1, B7-H3, poliovirus receptor-related 2 (PVRL2/CD112, ligand for TIGIT) and CD80 at relapse after allo-HCT compared to initial diagnosis (34). Here, CD274 is linked to acute myeloid leukemia.