This network shows the involvement of transcription factors such as BCL6, IRF1, NF-κB, STAT-1, and STAT-3, and the downstream production of cytokines and degradative enzymes such as IL-1β, TNF-α, IL-17, and MMP-1, -3 and -9, all of which are associated with RA. This evidence concerns the gene TNF and rheumatoid arthritis.