Furthermore, Akhtar et al. reported that miR-17-5p is reduced in RA serum and synovial tissue, inversely correlating with RA pathogenesis, and that overexpression of miR-17-5p inhibited TNF-α-induced production of IL-6, IL-8 and MMPs, suggesting that reduction of miR-17-5p expression may restore these pro-inflammatory and degradative processes (61). Here, IL6 is linked to rheumatoid arthritis.