CD14 and rheumatoid arthritis: In addition both MiR-125a-5p and miR-16-5p were significantly increased in RA vs Arthralgia, consistent with previous studies demonstrating higher levels in established RA and PsA (14, 53–56), with studies showing that they also mediate RAFLS function, macrophage plasticity and regulates pro-apoptotic and metabolic pathways in CD14+ monocytes (14, 53–57).