MiR-221-3p is elevated in both psoriatic arthritis and RA serum (14, 41), with in vitro studies demonstrating that its downregulation suppresses migration, invasion, and pro-inflammatory cytokine production by RA fibroblasts through the inhibition of vascular endothelial growth factor (VEGF) and MMPs (41). This evidence concerns the gene VEGFA and psoriatic arthritis.