CD4 and infection: In the contrast with Kennedy's results, Chuan He and Li Wu's group indicated that YTHDF1–3 proteins, which can bind to m6A-modified HIV-1 NL4.3 genome in HeLa/CD4+ T cells, suppress HIV-1 post-entry infection via degrading HIV-1 gRNA and inhibiting both early and late viral reverse transcription at 24 h post-infection (hpi) (59).