Monocytes from IPF patients showed a greater response to type I IFN stimulation for MX1, MX2; ISG15 and IFI44L (p=0.010, p=0.007, p= 0.008, and p= 0.029 respectively) (Figures 3O–S), regardless of the use of anti-fibrotic (Supplementary Figure 5). The gene discussed is ISG15; the disease is idiopathic pulmonary fibrosis.