Freshly isolated monocyte from IPF patients were stimulated with 100U/mL recombinant human IFN-β for 18 h and expression of key ISGs (STAT1, IRF7, MX1, MX2, ISG15, IFI44L), IFNA, and IFNB1 were examined. This evidence concerns the gene ISG15 and idiopathic pulmonary fibrosis.