More importantly, we could show that both IFN-γ and IL-6, two cytokines involved in lupus pathogenesis, significantly down-regulated Trap1 expression in spleen cells after in vitro culture (Figure 5D), whereas no change was observed with IFN-α or IL-17A (Supplementary Figure 5). The gene discussed is TRAP1; the disease is systemic lupus erythematosus.