The highest expression of CD69 was observed in the CD4+ fraction, which was increased 3.64-fold in T2D (p = 0.003 vs. ND), while the increase was 1.79-fold for the CD8+ fraction (p = 0.05 vs. ND) (Figures 2B,C). The gene discussed is CD8A; the disease is type 2 diabetes mellitus.