A genetic overlap was observed between susceptibility loci identified in GWAS for AITD or hypothyroidism and GWAS for thyroid function, including FOXE1, CAPZB, and PDE8B. FOXE1, also known as TTF-2 (thyroid transcription factor 2), is associated with hypothyroidism, and with TSH and fT4 levels, as well as with thyroid cancer (133, 143, 158, 162). This evidence concerns the gene CAPZB and hypothyroidism.