Similarly, expression analysis of genes from 11 GWAS-identified PCOS risk loci revealed that different mechanisms may be involved in the pathogenesis of clinically diverse PCOS subtypes in relation to obesity, since LHCGR is over-expressed in non-obese women and INSR is under-expressed only in obese women with PCOS. This evidence concerns the gene INSR and polycystic ovary syndrome.