The functional significance of this network is strongly supported by the discovery of the co-localization of LHCGR, DENND1A.V.2, and RAB5B proteins in theca cells (82), as well as the fact that decreased expression of miR-130b-3p, which is predicted to target DENND1A, correlates with increased V2 mRNA levels and androgen synthesis in PCOS theca cells (83). Here, DENND1A is linked to polycystic ovary syndrome.