INS and steatosis: In light of these observations, the aims of the present study were to i) determine the role of EDA in progressive NAFLD as assessed by severity of steatosis, inflammation, ballooning, and fibrosis in NAFLD by liver histology, ii) assess the utility of EDA as a biomarker of NAFLD and, iii) determine the relationships between EDA, insulin resistance and other hepatic and systemic measures of lipid and glucose metabolism, and inflammation.