Notably, after adjusting for history of hypertension, DBP, 2 h C peptide, serum uric acid, eGFR, TC and TG, the results demonstrated that alcohol consumption (odds ratio, OR = 2.984, 95% confidence interval (CI): 1.696–5.250, P = 0.000), BMI (OR = 1.183, 95% CI: 1.085–1.290, P = 0.000), PBG (OR= 1.082, 95% CI: 1.028–1.139, P = 0.003), 2 h insulin (OR= 1.019, 95% CI: 1.008–1.030, P = 0.001), LDL-C (OR= 3.600, 95% CI: 1.474–8.790, P = 0.005) and cathepsin S (OR= 1.055, 95% CI: 1.028–1.083, P = 0.000) remained significantly related to the CVD (Table 5). This evidence concerns the gene INS and Hypertension.