Considering the above-mentioned main points stating that the immune cells pattern changes to pro-inflammatory one with high level of IL-1 and TNF-α during a long-term hyperglycemia and regarding amplified immune responses to SARS-CoV-2 invasion in the lung of COVID-19 patients, this question arises that whether antidiabetic drugs with anti-inflammatory, anti-fibrotic, and anti-oxidant effects can be beneficial on prevention from infection with SARS-CoV-2 and even suffering from severe consequence of COVID-19. The gene discussed is TNF; the disease is COVID-19.