According to the results of the CD31 immunofluorescent staining of the peri-infarct region of T2DM stroke rats, a higher level of microvessel density was observed in the LV-APN-EPCs treatment group, which suggested that increased angiogenesis may play an important mechanistic role in protecting against ischemic stroke. The gene discussed is PECAM1; the disease is type 2 diabetes mellitus.