IL10 and schizophrenia: Additionally, it has recently been reported that IL-10-592A/C (rs1800872) polymorphisms interact with catechol-o-methyltransferase Val158Met (rs4680) polymorphisms to detrimentally impact cognitive function in schizophrenic patients (131), which is important in the light of cognitive deficits being core symptoms of schizophrenia (132, 133).