In granulosa cells (GCs) derived from PCOS patients and the ovarian tissues of PCOS rats, the expression levels of insulin growth factor 1 (IGF-1R) and Wnt family member 1 (Wnt1) were found to be decreased and PKB/AktSer473/Thr308 phosphorylation was lowered (Mao et al., 2018). The gene discussed is WNT1; the disease is polycystic ovary syndrome.