Moreover, the changes in FoxO1-mediated signaling may further induce the occurrence of low-grade chronic inflammation in the body, thereby leading to the hyperandrogenism of PCOS (Bremer and Miller, 2008; Rosas et al., 2010; Barthelmess and Naz, 2014; Nandi et al., 2014; Kamagate and Dong, 2018). This evidence concerns the gene FOXO1 and hyperandrogenism.