IL6 and polycystic ovary syndrome: A large number of studies have demonstrated a role of inflammation in the pathogenesis of PCOS (Alikhani et al., 2007), and the association of increased inflammatory markers, such as C reactive protein (CRP), ferritin, tumor necrosis factor (TNF) alpha, interleukin-6 (IL-6), and interleukin-18 (IL-18) with the occurrence of PCOS (González et al., 2006, 2007, 2012).