González et al. demonstrated that the expression of NF-kB increased in PCOS patients with high blood glucose, and the increased activity of NF-kB resulted in the secretion of pro-inflammatory cytokine TNF alpha (González et al., 2006, 2012; Escobar-Morreale et al., 2011). This evidence concerns the gene NFKB1 and polycystic ovary syndrome.