UCP2 expression variants were found to be associated with insulin sensitivity and diabetes mellitus (Jia et al., 2009; Diano and Horvath, 2012; Sreedhar and Zhao, 2017), obesity and metabolic syndrome (Li et al., 2003; Ricquier, 2007; Jia et al., 2009; Dinh et al., 2015; Sreedhar and Zhao, 2017), cardiac diseases (Brand and Esteves, 2005), immunity process (Emre et al., 2007; Emre and Nubel, 2010), tumorigenesis and cancer (Selimovic et al., 2008), aging (Brand and Esteves, 2005), and neurological diseases (Toda and Diano, 2014). This evidence concerns the gene INS and metabolic syndrome.