l-borneol can also inhibit neuronal apoptosis and enhance the stability of neovascularization by inhibiting the levels of ACE, MMP9, HIF1α, TGF-β1 and Tie2, thereby improving the neurological deficit in ischemic rats, reducing the rate of cerebral infarction, and exerting neuroprotective effects. Here, HIF1A is linked to brain infarction.