A KEGG enrichment analysis of hub nodes showed that the top ten signaling pathways with statistical significance, which overlapped with enriched signaling pathways related to RA targets, included the JAK/STAT signaling pathway, regulation of actin cytoskeleton, cytokine-cytokine receptor interaction, and the chemokine signaling pathways (Figure 3F). This evidence concerns the gene SOAT1 and rheumatoid arthritis.