Based on in vivo studies, we found that Ang-(1-7) can reduce the enlarged mesangial region, alleviate inflammation and fibrosis, and reduce oxidative stress in mice with diabetic nephropathy; the benefits of Ang-(1-7) were better than those of the ACEi (Mori et al., 2014; Zhang et al., 2015). This evidence concerns the gene ANG and diabetic kidney disease.