The activation of renin-angiotensin system and an elevated angiotensin II (Ang II) level are involved in various forms of acute kidney injury (Sato et al., 2012; Zhang et al., 2016; Chou et al., 2017; Chou et al., 2018; Safari et al., 2019; Sharma et al., 2019). This evidence concerns the gene REN and acute kidney injury.