NFKB1 and cancer: It can destroy cancer cells through several mechanisms, such as by increasing oxidative stress, by inducing apoptosis through the upregulation of Fas/FasL, NF-kB, p53, downregulating Bcl-2/Bcl-xl, Bax/Bak, and also through caspase-3 activation pathway, by inhibiting cell cycle through the inhibition of CDK-1 checkpoint and activation of CDK-1 inhibitors, p21.