They can exert anti-cancer activity by inhibiting cell proliferation, arresting cell cycle, inhibition of angiogenesis by downregulation various growth factors, metastasis and inducing cell death (apoptosis, autophagy, and paraptosis) through different mechanisms that involve death receptor, caspase 9 activation, or Bax/Bcl ratio (Abraham et al., 2019; Constantinou et al., 2020). The gene discussed is BAX; the disease is cancer.