RB1 and neoplasm: Preliminary work identified Gankyrin (Gank) as one of the key molecules elevated in HBL leading to tumor growth by triggering degradation of tumor suppressor proteins (TSPs) Rb, p53, C/EBPα, HNF4α, and CUGBP1 (Lewis et al., 2017; Cast et al., 2018; D’Souza et al., 2018; Valanejad et al., 2018).