According to the pathogenesis of ALI/ARDS, the KEGG pathway terms could be divided into inflammation (e.g., TNF signaling pathway and hypoxia inducible factor- (HIF-) 1 signaling pathway), immune response (e.g., T cell receptor signaling pathway and B cell receptor signaling pathway), energy metabolism (AMPK signaling pathway), and signal transduction (e.g., PI3K-protein kinase B (Akt) signaling pathway, Ras signaling pathway, and MAPK signaling pathway). This evidence concerns the gene PIK3CA and acute respiratory distress syndrome.