The enriched pathways include colorectal cancer pathway, human immunodeficiency virus 1 infection pathway, nonalcoholic fatty liver, proteoglycan in cancer and other pathways; immune related pathways include JAK-STAT signaling pathway, apoptosis, PI3K Akt signaling pathway and MAPK signaling pathway NF kappa B signaling pathway, T cell receptor signaling pathway and B cell receptor signaling pathway. This evidence concerns the gene AKT1 and colorectal cancer.