MAPT and Alzheimer disease: In AD patients with mild-to-moderate dementia, high t-tau and p-tau levels were variously associated with different BPSD, in particular agitation and apathy (Skogseth et al., 2008; Bloniecki et al., 2014), and an inverse correlation between Aβ42 and aggressiveness was observed (Engelborghs et al., 2006).