LQT8 can be regarded as part of a CACNA1C disease spectrum because with some variants the clinical phenotype can be either LQT8 alone (G402S, Mellor et al., 2019), LQT with syndactyly but without other TS-typical features (G402S, I1186T; Fröhler et al., 2014; Wemhöner et al., 2015) or Timothy syndrome. This evidence concerns the gene CACNA1C and Timothy syndrome.