CACNA1H and epilepsy: However, so far the association of most genetic variants in CACNA1G and CACNA1H and their functional mechanism of action in terms of GOF or LOF for idiopathic genetic epilepsies is less well understood (Weiss and Zamponi, 2019; Lory et al., 2020) and mutations in Cav3.1 or Cav3.2 causing high risk for epilepsy have not been described.