The expression of CRF is increased in the amygdala following brain injury (Narla et al., 2019; Tapp et al., 2019) and blockade of CRFR1 receptor 1 within the HPA axis attenuates post-traumatic stress and anxiety-like behaviors (Kosari-Nasab et al., 2019). The gene discussed is CRH; the disease is Anxiety.