Considered together, these results support the perspective that orexin neuron loss results in poor maintenance of wake, a common symptom of orexin deficiency in mouse models and human narcolepsy (Hara et al., 2001; Mochizuki et al., 2004; Tabuchi et al., 2014; Scammell, 2015). This evidence concerns the gene HCRT and narcolepsy.