Still, the hypothesis is open, and future research could determine whether DOX removal at birth or at weaning results in severe cataplexy in mice; examine whether age of orexin neuron loss affects reward-elicited cataplexy; characterize cataplexy in female mice as a function of estrus cycle; further parse out the acute and chronic effects of orexin neuron loss vs. orexin peptide loss on dark period REM sleep; or investigate compensatory mechanisms that develop in the weeks after orexin neuron loss. Here, HCRT is linked to Cataplexy.