It is also important to consider that all cataplexy reported here is spontaneous, but the addition of palatable food (Froot Loops or chocolate) or a running wheel can dramatically increase cataplexy in orexin knockout mice (Espana et al., 2007; Clark et al., 2009; Burgess et al., 2013; Oishi et al., 2013; Mahoney et al., 2017), and young-onset mice may be more vulnerable to reward-elicited cataplexy. The gene discussed is HCRT; the disease is Cataplexy.