These comorbidities can stimulate excessive inflammation by predisposing the patients to immune response suppression, infection with diverse viral quasispecies, respiratory tract mechanical dysfunction, sodium-fluid retention, negative effects on glucose metabolism, and insulin resistance, resulting in worse outcomes (Dixon and Peters, 2018[8]; Ferrannini and Cushman, 2012[9]; Gao et al., 2020[12]; Honce et al., 2020[17]; Rizos and Elisaf, 2014[26]; Saltiel and Olefsky, 2017[27]). The gene discussed is INS; the disease is infection.