ACE2 and infection: Research has proposed that angiotensin-converting enzyme 2 (ACE2) is overexpressed in various tissues of patients taking anti-hypertensive and anti-diabetic medication, which accelerates the SARS-CoV-2 binding, cell infection, and subsequently, SARS-CoV-2-mediated ACE2 reduction (Bornstein et al., 2020[5]).